WHICH DRUGS ARE CONSIDERED SEDATIVES? – FULL EXPLANATION

2. Histamine Receptor Antagonism: Some sedatives, for example antihistamines, exert their sedative effects by blocking histamine receptors from the Mind, especially H1 receptors. Histamine plays a role in wakefulness and arousal, so blocking its effects promotes sedation and sleepiness.Supplements: A number of supplements — which include valerian